Across TCGA cell cohorts, FAM186A mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM186A-associated genes across cancer lineages are PSMG2, PRDM14, and CTXN2. Each is linked with FAM186A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM186A-to-partner and partner-to-FAM186A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM186A→partner) and Y-score (partner→FAM186A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PSMG2 →	+0.643	+3.169	<.001	.006	3	2
OESOPHAGUS	PRDM14 →	+0.006	+4.017	<.001	.007	3	1
OESOPHAGUS	CTXN2 →	+0.029	+4.392	<.001	.003	3	1
CNS	GMNC →	+0.106	+3.479	.001	.009	3	1
CNS	DEFB133 →	+0.023	+4.357	<.001	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.021	+2.538	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

Exploration

FAM186A survival (RNA) · tumor vs normal (RNA) · all FAM186A data types