FAM182B

Across TCGA patient cohorts, FAM182B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM182B-associated genes across cancer lineages are mTOR_pS2448, ERK2, and IGFBP2. Each is linked with FAM182B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM182B-to-partner and partner-to-FAM182B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FAM182B-low versus FAM182B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM182B→partner) and Y-score (partner→FAM182B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.155	-2.986	.025	.035	3	2
UCEC	ERK2 →	+0.267	+3.169	.002	.018	3	1
UCEC	IGFBP2 →	-0.743	-2.584	.014	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.571	.010	.011	3	1
UCEC	MEK1 →	+0.447	+3.321	.008	.010	3	1
UCEC	Notch1 →	+0.232	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by FAM182B expression — UCEC

Explore this box plot interactively →