FAM181B

Across TCGA patient cohorts, FAM181B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FAM181B-associated genes across cancer lineages are INPP4B, ASNS, and Lck. Each is linked with FAM181B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM181B-to-partner and partner-to-FAM181B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by FAM181B-low versus FAM181B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM181B→partner) and Y-score (partner→FAM181B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.650	-2.991	<.001	.036	3	1
COAD	ASNS →	+0.423	+3.008	.039	.019	3	1
COAD	Lck →	+0.471	+3.025	.002	.019	2	1
COAD	EGFR_pY1068 →	-0.464	-2.991	.006	.036	1	1
COAD	PKC-b-II_pS660 →	-0.385	-2.991	.036	.036	1	1
COAD	PRDX1 →	+0.220	+3.025	.005	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

INPP4B by FAM181B expression — COAD

Explore this box plot interactively →