FAM181B

Across TCGA pan-cancer cohorts, FAM181B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FAM181B data layer compared with 1 for mutation status.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher FAM181B RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM181B expression acts as an unfavorable survival marker, although some lineages such as PAAD and UVM show a favorable association.

PAAD, UVM, and UCEC are the cancer types where FAM181B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Quartile	All	0.745	0.336	.001	60	view →
UVM	DFS	Quartile	All	0.992	0.413	<.001	55	view →
UCEC	DFS	Median	II,III,IV	0.883	0.765	.005	54	view →
BRCA	OS	Median	III,IV	0.659	0.426	<.001	53	view →
LUSC	DFS	Median	II,III,IV	0.686	0.495	.003	46	view →
CHOL	DFS	Median	All	0.762	0.120	.002	27	view →
DLBC	DFS	Median	III,IV	0.268	0.884	.004	21	view →
KIRC	DFS	Quartile	III,IV	0.632	0.314	.002	18	view →
TGCT	DFS	Median	All	0.705	0.880	.008	18	view →
ACC	DFS	Quartile	All	0.386	0.685	.010	17	view →
STAD	OS	Tertile	All	0.467	0.683	.008	14	view →
ESCA	OS	Median	All	0.593	0.415	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FAM181B–PAAD (OS)

Open the PAAD breakdown →