FAM181B

Across TCGA cell cohorts, FAM181B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FAM181B-associated genes across cancer lineages are SLC18A1, SCGB1C1, and TCP11X2. Each is linked with FAM181B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM181B-to-partner and partner-to-FAM181B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC18A1 grouped by FAM181B-low versus FAM181B-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM181B→partner) and Y-score (partner→FAM181B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC18A1 →	+0.016	+4.017	<.001	.007	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TCP11X2 →	+0.250	+5.060	<.001	.001	3	1
LARGE_INTESTINE	PPP1R2C →	+0.046	+4.095	<.001	.009	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SLC18A1 by FAM181B expression — OESOPHAGUS

Explore this box plot interactively →