FAM181A

Across TCGA patient cohorts, FAM181A mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM181A-associated genes across cancer lineages are KCTD9, CDKN3, and RNU6-1279P. Each is linked with FAM181A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM181A-to-partner and partner-to-FAM181A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by FAM181A-low versus FAM181A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM181A→partner) and Y-score (partner→FAM181A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.650	+2.595	.005	.006	3	3
SKCM	CDKN3 →	+0.704	+3.478	<.001	.002	3	3
READ	RNU6-1279P →	+0.539	+5.421	<.001	.005	3	2
COAD	SNORD113-4 →	+0.640	+2.956	<.001	.004	3	2
LUAD	KRTAP21-1 →	+0.067	+4.000	<.001	.009	3	2
LUAD	RNU6-340P →	+0.159	+4.000	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

KCTD9 by FAM181A expression — UCEC

Explore this box plot interactively →