FAM181A

Across TCGA pan-cancer cohorts, FAM181A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM181A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM181A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM181A is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and THCA are the cancer types where FAM181A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM181A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−1.783	<.001	8	view →
LUSC	Female	All	−1.682	<.001	8	view →
THCA	All	All	−0.670	<.001	7	view →
STAD	All	All	−0.094	.001	7	view →
BRCA	Female	II,III,IV	−0.213	<.001	6	view →
PRAD	All	All	−0.031	.008	2	view →
LIHC	Female	II,III,IV	+0.010	.035	2	view →
HNSC	All	All	+0.242	.039	1	view →
BLCA	Female	IV	−0.110	.030	1	view →
KIRC	Male	All	+0.006	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM181A–LUAD

Open the LUAD breakdown →