FAM181A

Across TCGA patient cohorts, FAM181A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM181A-associated genes across cancer lineages are ATM, Ku80, and PCNA. Each is linked with FAM181A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM181A-to-partner and partner-to-FAM181A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM181A-low versus FAM181A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM181A→partner) and Y-score (partner→FAM181A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.622	-3.321	.008	.010	3	2
UCEC	Ku80 →	+0.285	+2.183	.021	.035	3	1
UCEC	PCNA →	+0.272	+3.000	.016	.036	2	2
UCEC	VHL →	-1.273	-3.169	<.001	.019	3	1
COAD	Bax →	+0.250	+2.815	.042	.036	2	1
UCEC	ERK2 →	+0.217	+3.321	.031	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by FAM181A expression — UCEC

Explore this box plot interactively →