FAM181A

Across TCGA cell cohorts, FAM181A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM181A-associated genes across cancer lineages are LRRC74A, PNMA6F, and PPP1R17. Each is linked with FAM181A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM181A-to-partner and partner-to-FAM181A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC74A grouped by FAM181A-low versus FAM181A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM181A→partner) and Y-score (partner→FAM181A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LRRC74A →	+0.030	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUSC	PNMA6F →	+0.013	+4.643	<.001	.008	3	1
LARGE_INTESTINE	PPP1R17 →	+0.055	+4.467	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LRRC74A by FAM181A expression — PANCREAS

Explore this box plot interactively →