FAM178B

Across TCGA patient cohorts, FAM178B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM178B-associated genes across cancer lineages are c-Kit, 14-3-3_beta, and eEF2. Each is linked with FAM178B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM178B-to-partner and partner-to-FAM178B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by FAM178B-low versus FAM178B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM178B→partner) and Y-score (partner→FAM178B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.173	-1.222	.022	.035	3	2
UCEC	14-3-3_beta →	-0.106	-2.880	.001	.001	3	1
UCEC	eEF2 →	+0.372	+2.906	.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.208	-2.000	.010	<.001	3	1
UCEC	eIF4E →	+0.207	+3.713	.002	<.001	3	1
UCEC	eIF4G →	+0.274	+1.765	.006	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

c-Kit by FAM178B expression — UCEC

Explore this box plot interactively →