FAM178B

Across TCGA pan-cancer cohorts, FAM178B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM178B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM178B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM178B is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

THCA, LUAD, and HNSC are the cancer types where FAM178B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM178B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	+1.975	<.001	11	view →
LUAD	All	III,IV	+1.330	<.001	11	view →
HNSC	All	II,III,IV	+0.798	<.001	7	view →
KICH	All	All	−0.120	<.001	6	view →
BLCA	Male	III,IV	−1.124	.003	5	view →
LIHC	All	All	+0.536	<.001	4	view →
COAD	Female	All	+0.493	.005	4	view →
LUSC	All	All	+0.581	<.001	3	view →
PRAD	All	All	−0.441	<.001	2	view →
CHOL	Female	All	+0.140	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM178B–THCA

Open the THCA breakdown →