FAM178B

Across TCGA cell cohorts, FAM178B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FAM178B-associated genes across cancer lineages are CRYGD, PRR20B, and PRR20A. Each is linked with FAM178B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM178B-to-partner and partner-to-FAM178B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGD grouped by FAM178B-low versus FAM178B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM178B→partner) and Y-score (partner→FAM178B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CRYGD →	+0.037	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20E →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CRYGD by FAM178B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →