FAM177B

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAM177B mutation is significantly associated with the RNA expression of many other genes, with 1,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM177B-associated genes across cancer lineages are RNA5SP204, SEPTIN14P5, and ATP6V1E1P2. Each is linked with FAM177B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM177B-to-partner and partner-to-FAM177B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM177B→partner) and Y-score (partner→FAM177B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP204 →+0.310+2.151.005.00633
BRCASEPTIN14P5 →+0.129+8.055<.001.00732
SKCMATP6V1E1P2 →+0.087+3.186<.001.00132
UCECCHEK1 →+0.751+3.343.001.00532
UCECFEN1 →+0.684+3.459.004.00532
UCECC16orf91 →+0.623+2.828<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,020 associations by consensus.

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