Across TCGA pan-cancer cohorts, FAM177B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FAM177B data layer compared with 1 for mutation status.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM177B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM177B expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.
UCEC, HNSC, and LGG are the cancer types where FAM177B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.