Across TCGA pan-cancer cohorts, FAM177A1P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM177A1P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM177A1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM177A1P1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.
KIRC, THCA, and COAD are the cancer types where FAM177A1P1 tumor–normal differential expression is most reproducible.