FAM174A

Across TCGA patient cohorts, FAM174A mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM174A-associated genes across cancer lineages are MIR4439, PDCL3P1, and RNA5SP410. Each is linked with FAM174A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM174A-to-partner and partner-to-FAM174A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4439 grouped by FAM174A-low versus FAM174A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM174A→partner) and Y-score (partner→FAM174A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR4439 →	+0.451	+6.040	<.001	.001	3	2
LUAD	PDCL3P1 →	+0.076	+3.754	.009	.008	3	2
UCEC	RNA5SP410 →	+1.166	+4.110	<.001	<.001	3	2
UCEC	SNORD116-29 →	+0.719	+3.940	<.001	.001	3	2
UCEC	MIR3928 →	+0.694	+3.386	<.001	.008	3	2
BLCA	RNA5SP95 →	+0.316	+4.685	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

MIR4439 by FAM174A expression — BLCA

Explore this box plot interactively →