FAM172A

Across TCGA pan-cancer cohorts, FAM172A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of FAM172A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FAM172A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM172A is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

PDAC, COAD, and LSCC are the cancer types where FAM172A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM172A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.367	<.001	11	view →
COAD	Male	II,III,IV	−0.351	<.001	10	view →
LSCC	Male	All	−0.360	<.001	9	view →
HNSC	All	All	−0.322	<.001	8	view →
CCRCC	Male	All	+0.155	<.001	6	view →
LUAD	Male	All	−0.157	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

FAM172A–PDAC

Open the PDAC breakdown →