FAM172A

Across TCGA pan-cancer cohorts, FAM172A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FAM172A data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FAM172A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM172A expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, KICH, and HNSC are the cancer types where FAM172A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.716	0.543	<.001	155	view →
KICH	DFS	Median	All	0.680	0.977	<.001	57	view →
HNSC	DFS	Median	IV	0.720	0.560	.001	57	view →
LGG	OS	Median	All	0.754	0.868	<.001	49	view →
KIRP	OS	Median	All	0.902	0.986	<.001	48	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	42	view →
MESO	OS	Median	III,IV	0.464	0.249	.004	36	view →
BRCA	OS	Tertile	II,III,IV	0.498	0.647	.003	29	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LIHC	DFS	Quartile	III,IV	0.573	0.099	.002	23	view →
THCA	OS	Tertile	II,III,IV	0.791	0.969	.008	22	view →
READ	OS	Median	III,IV	0.842	0.299	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FAM172A–KIRC (DFS)

Open the KIRC breakdown →