FAM172A

Across TCGA patient cohorts, FAM172A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM172A-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with FAM172A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM172A-to-partner and partner-to-FAM172A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FAM172A-low versus FAM172A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM172A→partner) and Y-score (partner→FAM172A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.109	-1.973	.004	.029	3	1
UCEC	EGFR_pY1068 →	-0.318	-2.700	<.001	.006	3	1
UCEC	eIF4E →	+0.177	+2.087	.028	.005	3	1
UCEC	A-Raf_pS299 →	-0.148	-1.678	.001	.023	3	1
UCEC	ERK2 →	+0.180	+1.874	.015	.049	3	1
UCEC	G6PD →	-0.283	-2.571	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

14-3-3_beta by FAM172A expression — UCEC

Explore this box plot interactively →