FAM170B

Across TCGA patient cohorts, FAM170B mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM170B-associated genes across cancer lineages are PHF5A, COX7A2, and MRPS15. Each is linked with FAM170B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM170B-to-partner and partner-to-FAM170B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by FAM170B-low versus FAM170B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM170B→partner) and Y-score (partner→FAM170B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.434	+2.172	.004	.009	3	2
UCEC	COX7A2 →	+0.397	+2.181	.002	.009	3	2
UCEC	MRPS15 →	+0.369	+2.627	.008	.005	3	2
UCEC	DHDDS →	+0.398	+2.455	<.001	.001	3	2
UCEC	GOT1 →	+0.388	+2.566	.008	<.001	3	2
UCEC	SKA1 →	+0.610	+2.609	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

PHF5A by FAM170B expression — UCEC

Explore this box plot interactively →