FAM170B

Across TCGA pan-cancer cohorts, FAM170B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FAM170B data layer compared with 2 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FAM170B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM170B expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

UCS, KIRC, and LIHC are the cancer types where FAM170B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.579	0.189	.002	58	view →
KIRC	DFS	Tertile	II,III,IV	0.700	0.869	<.001	41	view →
LIHC	OS	Quartile	II,III,IV	0.417	0.670	.003	39	view →
MESO	OS	Tertile	All	0.228	0.595	.020	18	view →
UCEC	DFS	Tertile	IV	0.181	0.704	.027	18	view →
LAML	DFS	Tertile	All	0.440	0.624	.012	18	view →
READ	DFS	Tertile	II,III,IV	0.398	0.765	.005	15	view →
ACC	DFS	Tertile	All	0.845	0.595	.017	14	view →
BLCA	OS	Tertile	III,IV	0.677	0.531	.018	12	view →
ESCA	DFS	Tertile	II,III,IV	0.123	0.778	.015	9	view →
PCPG	DFS	Median	All	0.684	0.935	.016	9	view →
PRAD	OS	Tertile	All	0.972	0.995	.028	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FAM170B–UCS (DFS)

Open the UCS breakdown →