FAM170B

Across TCGA patient cohorts, FAM170B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM170B-associated genes across cancer lineages are ASNS, Di-Ras3, and 4E-BP1_pT37_T46. Each is linked with FAM170B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM170B-to-partner and partner-to-FAM170B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FAM170B-low versus FAM170B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM170B→partner) and Y-score (partner→FAM170B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.627	+2.815	.003	.036	3	2
UCEC	Di-Ras3 →	-0.198	-1.700	.001	.044	3	2
COAD	4E-BP1_pT37_T46 →	+0.501	+2.824	.006	.034	3	1
UCEC	14-3-3_beta →	-0.090	-2.973	.034	.035	3	1
UCEC	EGFR_pY1068 →	-0.373	-2.906	<.001	.001	3	1
UCEC	eIF4G →	+0.373	+3.321	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ASNS by FAM170B expression — COAD

Explore this box plot interactively →