FAM170B

Across TCGA cell cohorts, FAM170B mutation is significantly associated with the mutation status of many other genes, with 798 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM170B-associated genes across cancer lineages are MIB2, BDKRB1, and ACSBG1. Each is linked with FAM170B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM170B-to-partner and partner-to-FAM170B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIB2 grouped by FAM170B-low versus FAM170B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM170B→partner) and Y-score (partner→FAM170B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MIB2 →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	BDKRB1 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	ACSBG1 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	AREL1 →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	HELB →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	LPIN1 →	+4.772	+5.339	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 798 associations by consensus.

MIB2 by FAM170B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →