FAM168B

Across TCGA patient cohorts, FAM168B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM168B-associated genes across cancer lineages are FoxM1, INPP4B, and JNK_pT183_Y185. Each is linked with FAM168B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM168B-to-partner and partner-to-FAM168B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FAM168B-low versus FAM168B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM168B→partner) and Y-score (partner→FAM168B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.291	+2.807	.010	.003	3	1
UCEC	INPP4B →	-0.296	-2.999	.036	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-2.102	.003	.019	3	1
UCEC	Ku80 →	+0.343	+3.335	<.001	.005	3	1
UCEC	Notch1 →	+0.223	+2.807	<.001	.003	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.396	-2.321	.043	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FoxM1 by FAM168B expression — UCEC

Explore this box plot interactively →