FAM168B

Across TCGA pan-cancer cohorts, FAM168B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM168B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM168B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM168B is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where FAM168B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM168B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.758	<.001	11	view →
LIHC	Female	II,III,IV	+1.563	<.001	9	view →
THCA	All	II,III,IV	−0.632	<.001	9	view →
BLCA	Male	IV	−1.455	.004	7	view →
KICH	All	All	−0.794	<.001	7	view →
BRCA	All	III,IV	−0.769	<.001	6	view →
KIRC	Male	II,III,IV	−0.448	<.001	6	view →
CHOL	Male	All	+2.335	<.001	5	view →
LUSC	All	All	+0.389	<.001	5	view →
LUAD	Female	All	−0.462	<.001	4	view →
UCEC	All	All	−0.797	.001	2	view →
ESCA	Female	All	+0.726	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM168B–HNSC

Open the HNSC breakdown →