FAM166C

Across TCGA patient cohorts, FAM166C RNA expression is significantly associated with the protein abundance of many other proteins, with 12,341 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FAM166C-associated proteins across cancer lineages are MSH2, DNMT3A, and RHPN2. Each is linked with FAM166C in more than 4 cancer types. Because this analysis shows association rather than direction, both FAM166C-to-partner and partner-to-FAM166C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM166C versus MSH2 in HNSC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166C→partner) and Y-score (partner→FAM166C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSH2 →	+0.556	+0.687	<.001	<.001	3	5
LSCC	DNMT3A →	+0.569	+0.956	<.001	<.001	3	5
LUAD	RHPN2 →	+0.529	+0.683	<.001	<.001	3	4
GBM	AMPD3 →	-0.712	-0.616	<.001	<.001	3	4
LSCC	LIG3 →	+0.398	+0.651	<.001	<.001	3	4
HNSC	UCK2 →	+0.302	+0.514	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,341 associations by consensus.

FAM166C vs MSH2 — HNSC

Explore this scatter interactively →