FAM166C

Across TCGA cell cohorts, FAM166C RNA expression is significantly associated with the go_rna of many other GO terms, with 2,478 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FAM166C-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, ATP synthesis coupled electron transport, and Mitochondrial ATP synthesis coupled electron transport. Each is linked with FAM166C in more than 8 cancer types. Because this analysis shows association rather than direction, both FAM166C-to-partner and partner-to-FAM166C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by FAM166C-low versus FAM166C-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166C→partner) and Y-score (partner→FAM166C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.123	+2.279	<.001	<.001	3	9
OVARY	ATP synthesis coupled electron transport →	+0.098	+0.629	<.001	<.001	3	8
OVARY	Mitochondrial ATP synthesis coupled electron transport →	+0.098	+0.629	<.001	<.001	3	8
BREAST	Regulation of protein localization to nucleus →	+0.084	+0.543	<.001	.006	3	8
KIDNEY	Telomerase holoenzyme complex assembly →	+0.044	+1.512	<.001	.003	3	7
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.117	+0.962	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,478 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by FAM166C expression — LUNG_SCLC

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