FAM161B

Across TCGA pan-cancer cohorts, FAM161B mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM161B data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FAM161B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM161B expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM and LSCC are the cancer types where FAM161B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.438	0.212	.009	19	view →
LSCC	DFS	Median	All	1.000	0.530	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM161B–GBM (DFS)

Open the GBM breakdown →