FAM157C

Across TCGA patient cohorts, FAM157C mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FAM157C-associated genes across cancer lineages are RNU6-627P, RNY4P28, and RNU4-20P. Each is linked with FAM157C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM157C-to-partner and partner-to-FAM157C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-627P grouped by FAM157C-low versus FAM157C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM157C→partner) and Y-score (partner→FAM157C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-627P →	+0.333	+7.816	<.001	.008	3	1
SKCM	RNY4P28 →	+0.597	+7.816	<.001	.008	3	1
SKCM	RNU4-20P →	+0.244	+7.816	<.001	.008	3	1
SKCM	RNU6-768P →	+0.543	+7.816	<.001	.008	3	1
SKCM	RNU6-1148P →	+0.328	+7.816	<.001	.008	3	1
SKCM	RPS29P26 →	+0.718	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

RNU6-627P by FAM157C expression — SKCM

Explore this box plot interactively →