FAM157B

Across TCGA patient cohorts, FAM157B mutation is significantly associated with the RNA expression of many other genes, with 231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM157B-associated genes across cancer lineages are DHRS2, HAO1, and NUTF2. Each is linked with FAM157B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM157B-to-partner and partner-to-FAM157B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHRS2 grouped by FAM157B-low versus FAM157B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM157B→partner) and Y-score (partner→FAM157B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS2 →	+1.946	+3.343	<.001	.005	3	1
UCEC	HAO1 →	+0.205	+2.370	<.001	.007	3	1
UCEC	NUTF2 →	+0.460	+3.354	.005	.005	3	1
UCEC	SLC7A6OS →	+0.680	+3.354	<.001	.005	3	1
UCEC	DAP →	+0.562	+3.354	.008	.005	3	1
UCEC	ICMT →	+0.580	+3.343	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 231 associations by consensus.

DHRS2 by FAM157B expression — UCEC

Explore this box plot interactively →