FAM157A

Across TCGA patient cohorts, FAM157A mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM157A-associated genes across cancer lineages are FSCB, RNU6-170P, and RNA5SP516. Each is linked with FAM157A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM157A-to-partner and partner-to-FAM157A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSCB grouped by FAM157A-low versus FAM157A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM157A→partner) and Y-score (partner→FAM157A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FSCB →	+0.087	+4.026	<.001	.006	3	1
UCEC	RNU6-170P →	+0.494	+5.292	<.001	.002	3	1
UCEC	RNA5SP516 →	+0.427	+4.352	<.001	.008	3	1
UCEC	RNU6-366P →	+0.419	+4.641	<.001	.006	3	1
UCEC	RNU6-13P →	+0.768	+5.384	<.001	<.001	3	1
UCEC	RNU6-937P →	+0.633	+4.078	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FSCB by FAM157A expression — UCEC

Explore this box plot interactively →