FAM157A

Across TCGA pan-cancer cohorts, FAM157A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM157A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FAM157A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM157A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUSC, UCEC, and BLCA are the cancer types where FAM157A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM157A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	+0.842	<.001	6	view →
UCEC	All	All	+0.516	<.001	6	view →
BLCA	All	All	+0.370	.010	6	view →
COAD	All	II,III,IV	+0.153	.002	6	view →
KICH	All	All	−0.125	.003	6	view →
BRCA	Female	All	+0.153	.015	4	view →
LUAD	All	All	+0.354	<.001	3	view →
LIHC	All	All	+0.076	.020	3	view →
READ	All	II,III,IV	+0.464	.027	1	view →
HNSC	Male	All	+0.283	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM157A–LUSC

Open the LUSC breakdown →