FAM153A

Across TCGA cell cohorts, FAM153A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM153A-associated GO terms across cancer lineages are RNA destabilization, Regulation of RNA stability, and Regulation of mRNA stability. Each is linked with FAM153A in more than 6 cancer types. Because this analysis shows association rather than direction, both FAM153A-to-partner and partner-to-FAM153A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA destabilization grouped by FAM153A-low versus FAM153A-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM153A→partner) and Y-score (partner→FAM153A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNA destabilization →	+0.041	+0.107	<.001	.002	3	7
LARGE_INTESTINE	Regulation of RNA stability →	+0.031	+0.093	.001	.009	3	6
LARGE_INTESTINE	Regulation of mRNA stability →	+0.034	+0.141	.001	.007	3	6
BLOOD_Lymphoma	Negative regulation of mRNA splicing, via spliceosome →	+0.080	+0.490	<.001	.001	3	6
SOFT_TISSUE	Heterochromatin organization →	+0.051	+0.707	<.001	.007	3	6
SOFT_TISSUE	Negative regulation of myoblast fusion →	+0.062	+0.383	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,120 associations by consensus.

RNA destabilization by FAM153A expression — LARGE_INTESTINE

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