FAM153A

Across TCGA pan-cancer cohorts, FAM153A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FAM153A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM153A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM153A is over-expressed in tumor, although a few such as STAD and UCEC show the opposite, repressed pattern.

KIRC, STAD, and UCEC are the cancer types where FAM153A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM153A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.398	<.001	12	view →
STAD	All	IV	−0.170	.008	7	view →
UCEC	All	All	−0.296	<.001	6	view →
BRCA	All	III,IV	−0.171	<.001	6	view →
COAD	All	All	−0.056	.002	5	view →
LUSC	Male	III,IV	−0.370	<.001	4	view →
HNSC	Female	IV	−0.123	.020	4	view →
PRAD	All	All	−0.160	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FAM153A–KIRC

Open the KIRC breakdown →