FAM151B

Across TCGA pan-cancer cohorts, FAM151B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM151B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FAM151B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM151B expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

LSCC, PDAC, and GBM are the cancer types where FAM151B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.389	0.779	.018	22	view →
PDAC	DFS	Median	II,III,IV	0.543	0.245	.004	16	view →
GBM	OS	Tertile	All	0.783	0.898	.023	4	view →
LUAD	OS	Median	II,III,IV	0.820	0.352	.026	2	view →
HNSC	DFS	Median	II,III,IV	0.835	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM151B–LSCC (DFS)

Open the LSCC breakdown →