FAM151B

Across TCGA cell cohorts, FAM151B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM151B-associated genes across cancer lineages are ADAM2, OOSP2, and CLDN17. Each is linked with FAM151B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM151B-to-partner and partner-to-FAM151B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by FAM151B-low versus FAM151B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM151B→partner) and Y-score (partner→FAM151B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ADAM2 →	+0.027	+4.754	<.001	.005	3	1
CNS	OOSP2 →	+0.092	+4.321	<.001	.009	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	GKN1 →	+0.060	+3.510	<.001	.003	3	1
LARGE_INTESTINE	PYDC1 →	+0.185	+4.669	.004	<.001	3	1
LARGE_INTESTINE	RBMXL2 →	+0.097	+3.554	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ADAM2 by FAM151B expression — CNS

Explore this box plot interactively →