FAM13C

Across TCGA pan-cancer cohorts, FAM13C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM13C data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM13C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM13C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, LUAD, and UCEC are the cancer types where FAM13C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
LUAD	OS	Median	II,III,IV	0.273	0.759	<.001	28	view →
UCEC	DFS	Median	All	0.959	0.620	.016	6	view →
SKCM	OS	Median	III,IV	0.320	0.729	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM13C–ACC (DFS)

Open the ACC breakdown →