FAM13C

Across TCGA pan-cancer cohorts, FAM13C RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of FAM13C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM13C RNA is repressed in tumor relative to normal tissue. In most cancer types FAM13C is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where FAM13C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM13C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.121	<.001	10	view →
LUAD	Female	III,IV	−1.491	<.001	9	view →
COAD	Male	All	−0.670	<.001	9	view →
UCEC	All	All	−2.066	<.001	8	view →
LUSC	Female	All	−1.574	<.001	8	view →
LIHC	Male	All	+0.622	<.001	8	view →
KIRP	Male	All	−0.573	<.001	8	view →
BRCA	All	III,IV	−1.484	<.001	6	view →
HNSC	Male	All	−0.741	.001	6	view →
KICH	All	All	+1.052	.001	4	view →
BLCA	Male	IV	−0.985	.017	4	view →
CHOL	All	All	+0.565	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

FAM13C–THCA

Open the THCA breakdown →