FAM13C

Across TCGA patient cohorts, FAM13C mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM13C-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and mTOR_pS2448. Each is linked with FAM13C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM13C-to-partner and partner-to-FAM13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM13C-low versus FAM13C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM13C→partner) and Y-score (partner→FAM13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.318	-2.906	<.001	.001	3	2
UCEC	GAPDH →	+0.465	+2.700	.018	.005	3	2
UCEC	mTOR_pS2448 →	-0.144	-2.102	.008	.016	3	2
UCEC	PDCD4 →	-0.592	-2.247	<.001	.001	3	2
UCEC	PEA-15_pS116 →	+0.354	+1.502	.005	.030	3	2
UCEC	PI3K-p110-a →	-0.142	-2.247	.028	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR_pY1068 by FAM13C expression — UCEC

Explore this box plot interactively →