FAM13C

Across TCGA cell cohorts, FAM13C mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM13C-associated genes across cancer lineages are KRTAP10-12, IL2, and WFDC8. Each is linked with FAM13C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM13C-to-partner and partner-to-FAM13C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-12 grouped by FAM13C-low versus FAM13C-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM13C→partner) and Y-score (partner→FAM13C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRTAP10-12 →	+0.026	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	IL2 →	+0.040	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.012	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.025	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	LRRC10 →	+0.012	+3.866	<.001	.006	3	1
BLOOD_Lymphoma	FAM187B →	+0.052	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KRTAP10-12 by FAM13C expression — STOMACH

Explore this box plot interactively →