FAM13A

Across TCGA patient cohorts, FAM13A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM13A-associated genes across cancer lineages are eIF4E, FoxM1, and MEK1. Each is linked with FAM13A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM13A-to-partner and partner-to-FAM13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FAM13A-low versus FAM13A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM13A→partner) and Y-score (partner→FAM13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.143	+1.643	.013	.002	3	2
UCEC	FoxM1 →	+0.152	+1.540	.032	.001	3	2
UCEC	MEK1 →	+0.403	+1.722	<.001	<.001	3	2
UCEC	Notch1 →	+0.124	+1.750	.001	.003	3	2
UCEC	PDCD4 →	-0.510	-1.874	<.001	.001	3	2
UCEC	RAD51 →	+0.087	+1.247	.023	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by FAM13A expression — UCEC

Explore this box plot interactively →