Across TCGA pan-cancer cohorts, FAM138C RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM138C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FAM138C RNA is repressed in tumor relative to normal tissue. In most cancer types FAM138C is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

LUSC, UCEC, and LUAD are the cancer types where FAM138C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM138C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.015	.001	3	view →
UCEC	All	All	−0.022	.025	2	view →
LUAD	All	All	−0.011	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FAM138C RNA expression & survival · all FAM138C data types