FAM136A

Across TCGA patient cohorts, FAM136A mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM136A-associated genes across cancer lineages are TRAJ25, RNU6-618P, and RNA5SP205. Each is linked with FAM136A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM136A-to-partner and partner-to-FAM136A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ25 grouped by FAM136A-low versus FAM136A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM136A→partner) and Y-score (partner→FAM136A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ25 →	+0.556	+5.003	<.001	.004	3	2
UCEC	RNU6-618P →	+0.585	+4.121	<.001	<.001	3	2
UCEC	RNA5SP205 →	+0.508	+4.115	<.001	.001	3	2
UCEC	RNU6-1228P →	+0.253	+4.464	<.001	.005	3	2
UCEC	RNVU1-2A →	+0.953	+3.162	<.001	.004	3	1
UCEC	DNTT →	+0.424	+3.005	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

TRAJ25 by FAM136A expression — COAD

Explore this box plot interactively →