FAM135B

Across TCGA patient cohorts, FAM135B mutation is significantly associated with the total protein of many other genes, with 106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM135B-associated genes across cancer lineages are PCNA, Cyclin-B1, and FoxM1. Each is linked with FAM135B in more than 5 cancer types. Because this analysis shows association rather than direction, both FAM135B-to-partner and partner-to-FAM135B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FAM135B-low versus FAM135B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM135B→partner) and Y-score (partner→FAM135B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.215	+1.736	<.001	<.001	3	6
UCEC	Cyclin-B1 →	+0.672	+1.384	<.001	<.001	3	5
LUAD	FoxM1 →	+0.223	+1.453	.001	.012	3	4
LUSC	ER-alpha →	-0.143	-2.099	<.001	<.001	3	4
UCEC	ACVRL1 →	-0.135	-2.156	<.001	<.001	3	4
LUSC	p62 Lck ligand →	+0.275	+0.877	.026	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

PCNA by FAM135B expression — UCEC

Explore this box plot interactively →