FAM135B

Across TCGA pan-cancer cohorts, FAM135B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM135B data layer compared with 10 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher FAM135B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM135B expression acts as an unfavorable survival marker, although some lineages such as UVM and PAAD show a favorable association.

THCA, UVM, and PAAD are the cancer types where FAM135B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	All	0.887	0.958	<.001	132	view →
UVM	OS	Quartile	II,III,IV	1.000	0.436	.002	70	view →
PAAD	OS	Tertile	All	0.533	0.260	<.001	53	view →
COAD	DFS	Median	IV	0.628	0.344	.001	50	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.292	.002	38	view →
SKCM	OS	Quartile	All	0.451	0.291	.001	28	view →
KIRC	OS	Quartile	All	0.711	0.525	.003	26	view →
OV	OS	Quartile	IV	0.307	0.557	.006	26	view →
HNSC	OS	Tertile	All	0.629	0.878	<.001	25	view →
UCS	DFS	Quartile	II,III,IV	0.754	0.340	.023	20	view →
ACC	OS	Tertile	IV	0.783	0.307	.019	18	view →
LGG	OS	Median	All	0.932	0.854	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAM135B–THCA (DFS)

Open the THCA breakdown →