FAM135B

Across TCGA cell cohorts, FAM135B mutation is significantly associated with the RNA expression of many other genes, with 1,407 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM135B-associated genes across cancer lineages are TTC21B, GPR180, and SERAC1. Each is linked with FAM135B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM135B-to-partner and partner-to-FAM135B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC21B grouped by FAM135B-low versus FAM135B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM135B→partner) and Y-score (partner→FAM135B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTC21B →	+0.490	+3.489	.005	.001	3	3
LUNG_NSCLC_LUAD	GPR180 →	+0.457	+3.584	.001	<.001	3	3
BLOOD_Leukemia	SERAC1 →	+0.654	+3.412	.002	.002	3	3
BLOOD_Leukemia	CHRNA5 →	+0.918	+3.120	.006	.009	3	3
BLOOD_Leukemia	GPRC5C →	-1.261	-3.429	.005	.003	3	3
BLOOD_Leukemia	OR7D2 →	+0.377	+3.493	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,407 associations by consensus.

TTC21B by FAM135B expression — BLOOD_Leukemia

Explore this box plot interactively →