FAM135A

Across TCGA patient cohorts, FAM135A mutation is significantly associated with the RNA expression of many other genes, with 2,933 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM135A-associated genes across cancer lineages are C9orf50, RPL7P29, and CDC25A. Each is linked with FAM135A in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM135A-to-partner and partner-to-FAM135A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf50 grouped by FAM135A-low versus FAM135A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM135A→partner) and Y-score (partner→FAM135A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf50 →	-0.277	-1.530	.007	.003	3	4
PAAD	RPL7P29 →	+0.064	+5.392	<.001	.005	3	3
UCEC	CDC25A →	+0.366	+1.152	.006	.003	3	3
SKCM	CHAF1A →	+0.648	+4.006	<.001	<.001	3	3
UCEC	SRR →	+0.369	+1.280	<.001	<.001	3	3
UCEC	CNTROB →	+0.217	+1.595	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,933 associations by consensus.

C9orf50 by FAM135A expression — UCEC

Explore this box plot interactively →