FAM135A

Across TCGA cell cohorts, FAM135A mutation is significantly associated with the RNA expression of many other genes, with 527 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM135A-associated genes across cancer lineages are PRAMEF2, MINDY4B, and BTNL2. Each is linked with FAM135A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM135A-to-partner and partner-to-FAM135A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF2 grouped by FAM135A-low versus FAM135A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM135A→partner) and Y-score (partner→FAM135A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF2 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	MINDY4B →	+0.070	+4.906	<.001	.006	3	2
LUNG_SCLC	BTNL2 →	+0.402	+4.044	<.001	.009	3	2
OVARY	UQCRC2 →	+0.551	+3.078	.003	.007	3	2
STOMACH	DEFB103A →	+0.074	+3.584	.001	.009	3	2
LARGE_INTESTINE	EARS2 →	+0.411	+2.949	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 527 associations by consensus.

PRAMEF2 by FAM135A expression — OESOPHAGUS

Explore this box plot interactively →