Across TCGA pan-cancer cohorts, FAM133GP RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FAM133GP’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM133GP RNA is repressed in tumor relative to normal tissue. In most cancer types FAM133GP is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.
LUAD and KICH are the cancer types where FAM133GP tumor–normal differential expression is most reproducible.