FAM133B

Across TCGA pan-cancer cohorts, FAM133B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM133B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM133B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM133B is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where FAM133B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM133B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.735	<.001	8	view →
LSCC	All	All	+0.333	<.001	8	view →
PDAC	Male	All	−0.532	<.001	7	view →
CCRCC	Male	All	+0.162	.003	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM133B–HNSC

Open the HNSC breakdown →